4-[(AMMONIOOXY)METHYL]-1,2-DICHLOROBENZENE CHLORIDE

4-[(AMMONIOOXY)METHYL]-1,2-DICHLOROBENZENE CHLORIDE - Names and Identifiers

Name	4-[(Ammoniooxy)Methyl]-1,2-Dichlorobenzene Chloride
Synonyms	(3,4-dichlorophenyl)methoxyazanium,chloride O-(3,4-dichlor-benzyl)-hydroxylamin hydrochloride O-(3,4-Dichlorobenzyl)hydroxylamine hydrochloride 4-[(AMMONIOOXY)METHYL]-1,2-DICHLOROBENZENE CHLORIDE 4-[(Ammoniooxy)Methyl]-1,2-Dichlorobenzene Chloride O-(3,4-Dichloro--benzyl)hydroxylamine hydrochloride 4-[(AMINOOXY)METHYL]-1,2-DICHLOROBENZENE HYDROCHLORIDE 4-[(Aminooxy)Methyl]-1,2-Dichlorobenzene Hydrochloride
CAS	15256-10-7 84772-12-3
InChI	InChI=1/C7H7Cl2NO.ClH/c8-6-2-1-5(4-11-10)3-7(6)9;/h1-3H,4,10H2;1H

4-[(AMMONIOOXY)METHYL]-1,2-DICHLOROBENZENE CHLORIDE - Physico-chemical Properties

Molecular Formula	C7H8Cl3NO
Molar Mass	228.5
Melting Point	195°
Boling Point	195°C
Flash Point	158.8°C
Solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly, Heated)
Vapor Presure	6.77E-05mmHg at 25°C
Appearance	Solid
Color	White to Off-White
Storage Condition	Hygroscopic, -20°C Freezer, Under inert atmosphere

4-[(AMMONIOOXY)METHYL]-1,2-DICHLOROBENZENE CHLORIDE - Risk and Safety

Hazard Symbols	Xn - Harmful
Risk Codes	22 - Harmful if swallowed
Hazard Class	IRRITANT

4-[(AMMONIOOXY)METHYL]-1,2-DICHLOROBENZENE CHLORIDE - Introduction

4-[(Ammoniooxy)Methyl]-1,2-dichlorobenzene Chloride is an organic compound with the chemical formula C7H7Cl2NO · HCl. The following is a description of its nature, use, preparation and safety information:

Nature:
- 4-[(Ammoniooxy)Methyl]-1,2-dichlorobenzene Chloride is a colorless crystalline solid, soluble in water and organic solvents.
-It has a strong amine and salty taste.

Use:
- 4-[(Ammoniooxy)Methyl]-1,2-dichlorobenzene Chloride is used as an intermediate in drug synthesis, especially one of the key substrates for the synthesis of anti-cancer drugs.
-It can also be used as an amination reagent in organic synthesis reactions.

Method:
The synthesis of -4-[(Ammoniooxy)Methyl]-1,2-dichlorobenzene Chloride can usually be carried out by the following steps:
1. Condensation reaction of 3,4-dichlorobenzaldehyde with ammonia or amine to obtain the corresponding 3,4-dichlorobenzyl amide.
2. Then, 3,4-dichlorobenzoyl amine is reacted with an alkali solution to generate the corresponding 3,4-dichlorobenzoic acid.
3. Finally, 3,4-dichlorobenzoic acid is condensed with amine under alkaline conditions to generate 3,4-dichlorobenzyloxyamine.
4. This amine can react with hydrochloric acid to form 4-[(Ammoniooxy)Methyl]-1,2-dichlorobenzene Chloride.

Safety Information:
- 4-[(Ammoniooxy)Methyl]-1,2-dichlorobenzene Chloride is required to comply with relevant safety procedures when used.
-It may cause irritation and damage to the human body, so contact with skin, eyes and mucous membranes should be avoided.
-Use suitable personal protective equipment, such as protective gloves and glasses, while avoiding inhalation and contact.
-If you come into contact with the compound, flush the affected area with plenty of water and seek medical attention if necessary.
-When storing and handling, please comply with local regulations and keep it in a dry, cool place.

Last Update：2024-04-09 21:00:56